UTI Testing - Why Does It Matter?

Dr. Mara Holton and Kathleen Mackey
Dr. Mara Holton and Kathleen Mackey
December 12, 2022
3
min read
UTI Testing - Why Does It Matter?
Listen to this article

Urinary tract infections (UTIs) are common, uncomfortable, and disruptive. But with the right testing, they don’t have to be a guessing game.

UTIs happen when bacteria enter the urinary system and begin to multiply. The infection can affect different parts of the system, including the urethra, bladder, ureters, and kidneys. Most of the time, the infection begins in the lower tract (the bladder and urethra), where symptoms tend to be uncomfortable but manageable with prompt treatment [1].

Common symptoms include a strong or persistent urge to urinate, a burning sensation while peeing, cloudy or foul-smelling urine, and lower abdominal discomfort [1]. If the infection spreads to the kidneys, symptoms can become more severe and may include back pain, fever, or nausea [1]. In older adults, symptoms might be more subtle, such as fatigue or confusion [2]. This is why recognizing symptoms and testing early is so important.

Because these signs can overlap with other health issues, such as kidney stones or sexually transmitted infections, it’s important not to rely on conjecture. That’s where accurate UTI testing comes in.

Why UTI Testing Really Matters

Getting tested isn’t only for confirming an infection. It’s actually about making sure you get the right diagnosis and the best treatment possible. Testing is crucial for [3]:

1. Pinpointing the Cause

UTI-like symptoms can result from several different conditions. Testing helps distinguish whether the issue is a true UTI or something else entirely. Without proper testing, misdiagnosis is common and can delay healing or lead to inappropriate treatment.

2. Guiding the Right Treatment

Different bacteria cause different infections. UTI testing helps identify the specific culprit, allowing healthcare providers to prescribe the most effective antibiotic. Without this step, you might be given a medication that doesn’t work, allowing the infection to linger or worsen.

3. Avoiding Antibiotic Resistance

Taking unnecessary or incorrect antibiotics can fuel antibiotic resistance. That means future infections may be harder to treat. Testing facilitates the appropriate use of antibiotics.

4. Managing Recurring Infections

If you’ve had more than one UTI, you’re not alone. Recurrent infections are common. Testing helps uncover what’s triggering them, whether it’s a persistent bacterial strain or an underlying issue, and informs strategies to prevent them from continuing to recur.

Diagnosis of UTI

Not all UTI tests are created equal. Here are the most common diagnostic methods and what they’re best suited for:

Dipstick Urinalysis

This test checks for signs of infection by detecting blood, nitrites, or white blood cells in your urine. However, it does not detect specific bacteria that cause UTIs.

  • The presence of these cells may suggest an infection, but they could also be caused by other issues like kidney stones, vaginal contamination, or even urologic cancers.
  • False positives are common, which can lead to unnecessary antibiotic use or missed diagnoses of other conditions.
A urine dipstick test for UTIs is a fast and easy way to check for infection by looking for signs like bacteria and white blood cells in the urine.

Urine culture

This is often referred to as the "gold standard" for UTI testing, but it’s not perfect.

  • It only detects about 73% of UTIs, meaning over 25% of patients with a UTI may get a negative result. In these cases, the infection could go untreated.
  • If multiple organisms are present, the test may not identify all of them.
  • It can take anywhere from 2 to 10 days to get the results, which delays treatment.
A urine culture is a lab test that grows bacteria from a urine sample to identify if there's an infection and determine the best antibiotic for treatment.

Urine PCR

This is a more advanced test that’s highly accurate because it amplifies bacterial DNA in the urine.

  • You can get results in as little as 6 to 8 hours once the sample reaches the lab.
  • However, it only tests for specific organisms on a panel, so healthcare providers must use their clinical judgment when interpreting results.
  • It can also identify genes that make bacteria resistant to antibiotics, helping doctors choose the most effective treatment.
A urine PCR test checks for bacteria in a urine sample by looking for their DNA, helping to quickly and accurately diagnose infections.

Why At-Home Testing Makes Sense

For people managing recurrent infections or those who want to avoid unnecessary clinic visits, at-home testing is a smart option. Many people delay seeking care, unsure if symptoms point to a true infection or just irritation. Early testing helps confirm the issue so you can take appropriate action, whether that means starting treatment or contacting your doctor. It also helps to prevent complications, such as kidney infections, which can develop if a UTI goes untreated.

Diagnox offers a range of UTI testing solutions, including at-home urine dipstick tests for quick checks and lab-based PCR testing with fast, reliable results. Our at-home kits are easy to use, affordable, and backed by science. They let you screen symptoms early or track recurring issues without waiting days for appointments or prescriptions.

You can even order a test, collect your sample at home, and send it to our partner lab. Results are typically available within 24 to 48 hours. And because we work with certified labs and modern testing methods, you can trust the accuracy.

Why Accurate Testing is Important

While dipsticks, at-home testing strips, and questionnaires can help figure out whether your symptoms are due to a UTI or STI, definitive testing is key to identifying the exact cause. This allows your healthcare provider to select the right antibiotic or therapy, avoiding unnecessary treatments and helping you recover faster. Working with a healthcare provider who understands the pros and cons of each test is crucial for getting the right care!

At-home UTI test kits offer a fast, private, and easy way to detect common infection markers, including white blood cells and nitrites. While these kits don’t replace clinical diagnosis, they serve as a crucial first step. They help you monitor symptoms, catch patterns early, and decide when further care is needed.

Diagnox’s UTI testing kits are designed to give you peace of mind and clarity at every step. Explore our options and take control of your health from the comfort of home.

Clear information is the most valuable resource you can have on your side.
Stay in the loop!
Thank you for subscribing. Stay informed, stay healthy!
Oops! There was a problem with your submission. Please check your email address and try again.

About the Authors:

Dr. Mara Holton and Kathleen Mackey first met in 2007 while practicing general urology with a large local urology group.  At the time, Dr. Holton had just recently completed her urologic residency at the University of Maryland, and Kathleen had been in practice with the group as a CRNP for just over a year.  

Although both practiced general urology, over the years, the majority of their patient population became women experiencing recurrent urinary tract infections, urinary incontinence, uncomfortable vaginal symptoms, and difficulty with sexual activity.  They quickly found a common theme that many women had experienced these symptoms for years prior to identifying a provider who could address their concerns.  Unfortunately, many patients recounted that, when they did seek help, they were often undertreated, misdiagnosed, or led to believe their symptoms were just something that had to be tolerated. Many women described scenarios of being brushed off by male providers or told that their symptoms were a normal part of aging. As active women and mothers themselves, Mara & Kathleen empathized with the burden these conditions caused and the associated negative impacts on the quality and enjoyment of life.  In developing Snippa, a female-focused health care platform,  Mara and Kathleen seek to broaden and expand their reach and efforts in order to educate patients about pelvic health and to advocate for access to care, research into , and the development of treatment alternatives for these prevalent health conditions.

References

[1] Ahmed, S., Alsalloom, A, Babikir, I., Alhoumoud, B. (2019). Uropathogens and their antimicrobialvpatterns: Relationship with urinary tract infections. International Journal of Health Sciences. 2019 Mar-Apr; 12 (2): 48-55.

[2] Chua, K.-P., Fischer, M. A., & Linder, J. A. (2019). Appropriateness of outpatient antibiotic prescribing among privately insured US patients: ICD-10-CM based Cross Sectional Study. BMJ.

[3] Davenport M, Mach KE, Shortliffe LMD, Banaei N, Wang TH, Liao JC. New and developing diagnostic technologies for urinary tract infections. Nat Rev Urol. 2017;14(5):296-310.

[4] García LT, Cristancho LM, Vera EP, Begambre O. A New Multiplex-PCR for Urinary Tract Pathogen Detection Using Primer Design Based on an Evolutionary Computation Method. J Microbiol Biotechnol. 2015 Oct;25(10):1714-27.

[5] LaMotte, S. (2021, February 24). Doctors treat female UTIs with wrong antibiotics nearly half the time, study finds. CNN. Retrieved Dec 11, 2022.

[6] Mambatta, A. K., Jayarajan, J., Rashme, V. L., Harini, S., Menon, S., & Kuppusamy, J. (2015). Reliability of dipstick assay in predicting urinary tract infection. Journal of family medicine and primary care, 4(2), 265–268.

[7] Cleveland Clinic Staff, “Urinary Tract Infections,” Cleveland Clinic, Available Online. [Accessed May 25, 2025].

[8] C. Dutta, K. Pasha, S. Paul, et al., “Urinary Tract Infection Induced Delirium in Elderly Patients: A Systematic Review,” Cureus, vol. 14, pp. e32321, Dec 2022.

[9] National Kidney Foundation Staff, “Urinary Tract Infections: Core Curriculum 2024,” National Kidney Foundation, Available Online. [Accessed May 25, 2025].

[10] J. A. Simerville, W. C. Maxted, J. J. Pahira, “Urinalysis: a comprehensive review,” Am Fam Physician, vol. 71, pp. 1153-62, Mar 2005.

[11] NIH Staff, “Urinary Culture,” NIH, Available Online. [Accessed May 25, 2025].

[12] A. Szlachta-McGinn, K. M. Douglass, U. Y. Chung, et al., “Molecular diagnostic methods versus conventional urine culture for diagnosis and treatment of urinary tract infection: a systematic review and meta-analysis,” EU Open Sci., vol. 44, pp. 113-24, Oct 2022.

[13] K. J. Wojno, D. Baunoch, N. Luke, et al., “Multiplex PCR based urinary tract infection (UTI) analysis compared to traditional urine culture in identifying significant pathogens in symptomatic patients,” Urology, vol. 136, pp. 119-26, Feb 2020.

[14] ThermoFisher Scientific Staff, “Challenging the UTI Testing Gold Standard: PCR vs. SUC,” ThermoFisher Scientific, Available Online, s-suc/. [Accessed May 25, 2025].

About the Author
Dr. Mara Holton and Kathleen Mackey

Dr. Mara Holton and Kathleen Mackey first met in 2007 while practicing general urology with a large local urology group.  At the time, Dr. Holton had just recently completed her urologic residency at the University of Maryland, and Kathleen had been in practice with the group as a CRNP for just over a year.  

Although both practiced general urology, over the years, the majority of their patient population became women experiencing recurrent urinary tract infections, urinary incontinence, uncomfortable vaginal symptoms, and difficulty with sexual activity.  They quickly found a common theme that many women had experienced these symptoms for years prior to identifying a provider who could address their concerns.  Unfortunately, many patients recounted that, when they did seek help, they were often undertreated, misdiagnosed, or led to believe their symptoms were just something that had to be tolerated. Many women described scenarios of being brushed off by male providers or told that their symptoms were a normal part of aging. As active women and mothers themselves, Mara & Kathleen empathized with the burden these conditions caused and the associated negative impacts on the quality and enjoyment of life.  In developing Snippa, a female-focused health care platform,  Mara and Kathleen seek to broaden and expand their reach and efforts in order to educate patients about pelvic health and to advocate for access to care, research into , and the development of treatment alternatives for these prevalent health conditions.

About the Reviewer
This blog was
Medically reviewed by:
Dr. Mara Holton and Kathleen Mackey

Dr. Mara Holton and Kathleen Mackey first met in 2007 while practicing general urology with a large local urology group.  At the time, Dr. Holton had just recently completed her urologic residency at the University of Maryland, and Kathleen had been in practice with the group as a CRNP for just over a year.  

Although both practiced general urology, over the years, the majority of their patient population became women experiencing recurrent urinary tract infections, urinary incontinence, uncomfortable vaginal symptoms, and difficulty with sexual activity.  They quickly found a common theme that many women had experienced these symptoms for years prior to identifying a provider who could address their concerns.  Unfortunately, many patients recounted that, when they did seek help, they were often undertreated, misdiagnosed, or led to believe their symptoms were just something that had to be tolerated. Many women described scenarios of being brushed off by male providers or told that their symptoms were a normal part of aging. As active women and mothers themselves, Mara & Kathleen empathized with the burden these conditions caused and the associated negative impacts on the quality and enjoyment of life.  In developing Snippa, a female-focused health care platform,  Mara and Kathleen seek to broaden and expand their reach and efforts in order to educate patients about pelvic health and to advocate for access to care, research into , and the development of treatment alternatives for these prevalent health conditions.

Have a Question?

Questions are great. Drop us a note and we promise to get back to you soon.

Thank you! Your question has been received.
We will respond to you promptly.
Oops! Something went wrong while submitting the form. Kindly try again.
If the problem persists, please drop us an email at contact@diagnoxhealth.com